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5-Amino-1MQ

5-Amino-1-Methylquinolinium5A1MQNNMTiCAS: 42464-96-0Research Use Only

A selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) that modulates NAD+ salvage and lipogenesis pathways in preclinical metabolic research models. Premium Research Peptide.

$49.99

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Verified Test Results

Every batch, independently verified.

Each batch is analyzed by an ISO/IEC 17025 accredited third-party laboratory. The report below reflects the identity, purity and full-panel specification data released with this product.

ILSILS Laboratories

Certificate of Analysis

99%

Purity by HPLC

ISO 17025 Accredited8× Tested
ParameterResultSpecification
AppearanceGoodMeets spec
Purity99.97% · Pass≥ 95%
Net Peptide Content51.64mgReport
IdentityConfirmedMeets spec
Fentanyl ScreenNot DetectedPass
Heavy MetalsNot DetectedPass
SterilityNo GrowthPass
Endotoxin< 0.05 EU/mLReported

Representative report from lot AMQ0002 (5-Amino-1MQ). Your order ships with its own lot-specific certificate.

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Third-party verified

Certificate of Analysis

Every lot is HPLC-tested at an ISO/IEC 17025-accredited lab. Open any batch's certificate below.

5-Amino-1MQ 50mg

Latest

LOT AMQ0002

99.97%

HPLC purity · meets spec

Labeled
50mg
Measured
51.64mg
Identity
Confirmed
Heavy metals
Not Detected
Sterility
No Growth
Endotoxin
< 0.05 EU/mL
Tested
Jul 30, 2026

8 assays passed · ISO/IEC 17025 accredited

View certificate

Compound Information

Technical specifications

Molecular Profile

What Is 5-Amino-1MQ?

TypeSmall molecule NNMT inhibitor
CAS Number42464-96-0
Molecular Weight159.21 g/mol (cation)
Salt Form286.11 g/mol (iodide salt)
FormulaC₁₀H₁₁N₂⁺ (cation)
AppearanceBrown to reddish-brown solid
PubChem / J. Med. Chem. 2017
Storage Requirements

Stability Information

Soluble in DMSOAvoid repeated freeze-thawAliquot after reconstitution
Lyophilized (powder)
-20°Cstable 24+ months
Short-term storage
2-8°Cup to 30 days
Reconstituted
2-8°C

Sources & References

Peer-reviewed research

Journal of Medicinal Chemistry

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

2017DOI: 10.1021/acs.jmedchem.7b00389PMID: 28548833

Neelakantan H, Wang HY, Vance V et al.

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Biochemical Pharmacology

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

2018DOI: 10.1016/j.bcp.2017.11.007PMID: 29155147

Neelakantan H, Vance V, Wetzel MD et al.

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Biochemical Pharmacology

Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle

2019DOI: 10.1016/j.bcp.2019.02.008PMID: 30753815

Neelakantan H, Brightwell CR, Graber TG et al.

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Scientific Reports

Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

2021DOI: 10.1038/s41598-021-85051-6PMID: 33707534

Sampson CM, Dimet AL, Neelakantan H et al.

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Journal of Pharmaceutical and Biomedical Analysis

Development & validation of LC-MS/MS assay for 5-amino-1-methyl quinolinium in rat plasma: Application to pharmacokinetic and oral bioavailability studies

2021DOI: 10.1016/j.jpba.2021.114255PMID: 34304009

Awosemo O, Neelakantan H, Watowich S et al.

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Journal of Obstetrics and Gynaecology

Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells

2021DOI: 10.1080/01443615.2020.1854696PMID: 33645410

Akar S, Duran T, Azzawri AA et al.

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Scientific Reports

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

2022DOI: 10.1038/s41598-021-03670-5PMID: 35013352

Dimet-Wiley A, Wu Q, Wiley JT et al.

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Diabetes, Obesity and Metabolism

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction

2024DOI: 10.1111/dom.15879PMID: 39161060

Babula JJ, Bui D, Stevenson HL et al.

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Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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